Cisplatin and apoptosis

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August undefined, 2024

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. WebMay 1, 2008 · Interestingly, cisplatin can also induce necrosis and apoptosis in cultured endothelial cells, although evidence is yet to be demonstrated for endothelial cell apoptosis during cisplatin nephrotoxicity in vivo. 44 APOPTOTIC PATHWAYS IN CISPLATIN NEPHROTOXICITY

Is cisplatin-induced cell death always produced by …

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), w … WebFeb 13, 2024 · Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. dancing on the head of the serpent

Synergistic interaction between cisplatin and PARP inhibitors in …

WebTo further confirm that CYP1B1 is the executor of the UCA1/miR-513a-3p/CYP1B1 molecular axis regulating GC cell apoptosis induced by cisplatin, we simultaneously … WebMar 15, 2024 · Cell viability and proliferation were detected by counting kit 8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays respectively. Apoptosis and cell cycle were analyzed by flow cytometry. The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. WebMar 15, 2013 · The antineoplastic agent cis-diammineplatinum (II) dichloride (cisplatin, CDDP) is part of the poorly effective standard treatment of non-small cell lung carcinoma (NSCLC). Here, we report a novel strategy to improve the efficacy of CDDP. birkenstock company sale

Cisplatin Cancer information Cancer Research UK

Necroptosis and Apoptosis Contribute to Cisplatin and ... - PubMed

WebSynergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Authors Min Liu 1 , Shumei Ma 2 , Mingbo Liu 2 , Yufei Hou 2 , Bing Liang 2 , Xu Su 3 , Xiaodong Liu 4 Affiliations WebOct 5, 2014 · Because cisplatin is a DNA-damaging agent and an inducer of apoptosis, it is reasonable to expect changes in HSPs in the development of cellular resistance … dancing on the hood 英訳WebDec 12, 2024 · Cisplatin-induced AKI is characterised by increased apoptosis of renal tubular epithelial cells, and the results of the present study demonstrated that PSTPIP2 … dancing on the moon lyrics isla vista worship

"WebMar 9, 2024 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. " - Cisplatin and apoptosis

Cisplatin and apoptosis

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WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … WebAug 6, 2015 · It has been reported that cisplatin induces the expression of p53, which plays diverse roles, particularly in regulating glycolysis genes [ 8 – 11 ]. Down-regulation of glycolysis genes when p53 is over-expressed leads to apoptosis. Moreover, energy status of cell is the main determining factor in cell survival or cell death.

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WebSep 5, 2011 · Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res 15: 1645–1654. WebIn summary, a growing body of evidence suggests that cisplatin-induced cell death does not always come from "classic"apoptosis. Depending on both cisplatin dose and cellular …

WebJan 29, 2024 · Apoptosis and necroptosis were previously reported to be the major pathological processes of acute kidney injury, however, preclinical works using specific inhibitor of neither apoptosis or... WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and …

WebIt has been reported that cisplatin upregulates the expression levels of Trail, initiator caspase 8, and effector caspase 3, leading to apoptosis in hES [14]. The upregulation of p53, caspase... WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ...

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 …

WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin is … birkenstock concord new hampshireWebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … dancing on the jetty lyrics inxsWebJan 30, 2024 · While apoptosis activation pathways were not observed in DRG sensory neurons of cisplatin-treated mice, these neurons did express several senescence hallmarks, including senescence-associated β-galactosidase, phospho-H2AX, and nuclear factor kappa B (Nfkb)-p65 proteins. birkenstock company websiteWebMar 25, 2024 · Furthermore, RRS1 also induces apoptosis resistance in breast cancer cells through the ERK/Bcl-2/BAX signaling pathway. Our study is the first to show that RRS1 sensitizes breast cancer cells to cisplatin by binding to AEG-1, and it provides a theoretical basis to improve the efficacy of cisplatin-based chemotherapy. dancing on the keys book 2WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … birkenstock con le calzeWebMar 29, 2024 · In addition to TNF-α mediated apoptosis, cisplatin activates the p53 pathway, which can be a result of elevated ROS or induced as a response to elevated ROS from the intrinsic pathway. Treatment with cisplatin results in an increased expression and activation of the p53 protein since it regulates apoptosis of proximal tubular cells via ... dancing on the pedals phil liggettWebActivated P13K/Akt/mTOR pathway attenuates the antitumor effects of chemotherapeutics leading to cancer cells survival and its proliferation, 53 which plays a pivotal role in … birkenstock concord nh